[123I]beta-CIT SPECT demonstrates decreased brain dopamine and serotonin transporter levels in untreated parkinsonian patients.
Identifieur interne : 004644 ( Main/Exploration ); précédent : 004643; suivant : 004645[123I]beta-CIT SPECT demonstrates decreased brain dopamine and serotonin transporter levels in untreated parkinsonian patients.
Auteurs : T H Haapaniemi [Finlande] ; A. Ahonen ; P. Torniainen ; K A Sotaniemi ; V V MyllylSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.
English descriptors
- KwdEn :
- Adult, Aged, Binding, Competitive, Biological Transport (physiology), Brain (metabolism), Carrier Proteins (metabolism), Caudate Nucleus (metabolism), Dopamine (metabolism), Female, Frontal Lobe (metabolism), Humans, Iodine Radioisotopes (diagnostic use), Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (metabolism), Putamen (metabolism), Serotonin (metabolism), Severity of Illness Index, Thalamus (metabolism), Tomography, Emission-Computed, Single-Photon.
- MESH :
- chemical , diagnostic use : Iodine Radioisotopes.
- chemical , metabolism : Carrier Proteins, Dopamine, Serotonin.
- diagnosis : Parkinson Disease.
- metabolism : Brain, Caudate Nucleus, Frontal Lobe, Parkinson Disease, Putamen, Thalamus.
- physiology : Biological Transport.
- Adult, Aged, Binding, Competitive, Female, Humans, Male, Middle Aged, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon.
Abstract
Striatal dopamine transporters (DATs) and serotonin transporters (SERTs) were evaluated in untreated patients with Parkinson's disease (PD) and controls using single-photon emission computed tomography (SPECT) with 2beta-carboxymethoxy-3beta-(4-iodophenyl)tropane ([123I]beta-CIT). The striatal DAT specific to non-displaceable uptake ratios of 29, and the SERT uptake measurements of 27, PD patients were compared with those of 21 and 16 controls, respectively. The results were correlated with Unified Parkinson's Disease Rating Scale (UPDRS) scores, the Hoehn & Yahr stage, age, duration of the disease, and the major PD signs. The specific DAT binding in the caudate, the putamen and the caudate/putamen ratio were measured. In all of the PD patients the striatal uptake values were bilaterally reduced, being 36.9% (P < 0.001) lower than those of the controls. In the hemiparkinsonian patients the reduction was greater on the side contralateral to the initial symptoms (33.3% vs. 27.8%) and the uptake ratios indicated a more pronounced deficit in the putamen (39.1%) than in the caudate (27.9%). The DAT uptake correlated with the UPDRS total score and activities of daily living (ADL) and motor subscores, the Hoehn & Yahr stage, and rigidity score. PD patients had significantly higher caudate to putamen ratios than the controls. In the PD patients the SERT values were lower in the thalamic and frontal regions. The SERT uptake ratio of the frontal area correlated with the UPDRS subscore I. [123I]beta-CIT SPECT provides a useful method for confirming the clinical diagnosis of PD with correlation to disease severity. Additionally, this technique allows the simultaneous measurement of SERT uptake and shows that PD patients, interestingly, seem to have decreased SERT availability in the thalamic and frontal areas.
PubMed: 11215571
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[123I]beta-CIT SPECT demonstrates decreased brain dopamine and serotonin transporter levels in untreated parkinsonian patients.</title><author><name sortKey="Haapaniemi, T H" sort="Haapaniemi, T H" uniqKey="Haapaniemi T" first="T H" last="Haapaniemi">T H Haapaniemi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Oulu</wicri:regionArea><wicri:noRegion>University of Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Ahonen, A" sort="Ahonen, A" uniqKey="Ahonen A" first="A" last="Ahonen">A. Ahonen</name></author><author><name sortKey="Torniainen, P" sort="Torniainen, P" uniqKey="Torniainen P" first="P" last="Torniainen">P. Torniainen</name></author><author><name sortKey="Sotaniemi, K A" sort="Sotaniemi, K A" uniqKey="Sotaniemi K" first="K A" last="Sotaniemi">K A Sotaniemi</name></author><author><name sortKey="Myllyl, V V" sort="Myllyl, V V" uniqKey="Myllyl V" first="V V" last="Myllyl">V V Myllyl</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11215571</idno><idno type="pmid">11215571</idno><idno type="wicri:Area/PubMed/Corpus">003E24</idno><idno type="wicri:Area/PubMed/Curation">003E24</idno><idno type="wicri:Area/PubMed/Checkpoint">003C08</idno><idno type="wicri:Area/Ncbi/Merge">000427</idno><idno type="wicri:Area/Ncbi/Curation">000427</idno><idno type="wicri:Area/Ncbi/Checkpoint">000427</idno><idno type="wicri:doubleKey">0885-3185:2001:Haapaniemi T:i:beta:cit</idno><idno type="wicri:Area/Main/Merge">006910</idno><idno type="wicri:Area/Main/Curation">004644</idno><idno type="wicri:Area/Main/Exploration">004644</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[123I]beta-CIT SPECT demonstrates decreased brain dopamine and serotonin transporter levels in untreated parkinsonian patients.</title><author><name sortKey="Haapaniemi, T H" sort="Haapaniemi, T H" uniqKey="Haapaniemi T" first="T H" last="Haapaniemi">T H Haapaniemi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Oulu</wicri:regionArea><wicri:noRegion>University of Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Ahonen, A" sort="Ahonen, A" uniqKey="Ahonen A" first="A" last="Ahonen">A. Ahonen</name></author><author><name sortKey="Torniainen, P" sort="Torniainen, P" uniqKey="Torniainen P" first="P" last="Torniainen">P. Torniainen</name></author><author><name sortKey="Sotaniemi, K A" sort="Sotaniemi, K A" uniqKey="Sotaniemi K" first="K A" last="Sotaniemi">K A Sotaniemi</name></author><author><name sortKey="Myllyl, V V" sort="Myllyl, V V" uniqKey="Myllyl V" first="V V" last="Myllyl">V V Myllyl</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Binding, Competitive</term><term>Biological Transport (physiology)</term><term>Brain (metabolism)</term><term>Carrier Proteins (metabolism)</term><term>Caudate Nucleus (metabolism)</term><term>Dopamine (metabolism)</term><term>Female</term><term>Frontal Lobe (metabolism)</term><term>Humans</term><term>Iodine Radioisotopes (diagnostic use)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (metabolism)</term><term>Putamen (metabolism)</term><term>Serotonin (metabolism)</term><term>Severity of Illness Index</term><term>Thalamus (metabolism)</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Iodine Radioisotopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Carrier Proteins</term><term>Dopamine</term><term>Serotonin</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Caudate Nucleus</term><term>Frontal Lobe</term><term>Parkinson Disease</term><term>Putamen</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Biological Transport</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Binding, Competitive</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Striatal dopamine transporters (DATs) and serotonin transporters (SERTs) were evaluated in untreated patients with Parkinson's disease (PD) and controls using single-photon emission computed tomography (SPECT) with 2beta-carboxymethoxy-3beta-(4-iodophenyl)tropane ([123I]beta-CIT). The striatal DAT specific to non-displaceable uptake ratios of 29, and the SERT uptake measurements of 27, PD patients were compared with those of 21 and 16 controls, respectively. The results were correlated with Unified Parkinson's Disease Rating Scale (UPDRS) scores, the Hoehn & Yahr stage, age, duration of the disease, and the major PD signs. The specific DAT binding in the caudate, the putamen and the caudate/putamen ratio were measured. In all of the PD patients the striatal uptake values were bilaterally reduced, being 36.9% (P < 0.001) lower than those of the controls. In the hemiparkinsonian patients the reduction was greater on the side contralateral to the initial symptoms (33.3% vs. 27.8%) and the uptake ratios indicated a more pronounced deficit in the putamen (39.1%) than in the caudate (27.9%). The DAT uptake correlated with the UPDRS total score and activities of daily living (ADL) and motor subscores, the Hoehn & Yahr stage, and rigidity score. PD patients had significantly higher caudate to putamen ratios than the controls. In the PD patients the SERT values were lower in the thalamic and frontal regions. The SERT uptake ratio of the frontal area correlated with the UPDRS subscore I. [123I]beta-CIT SPECT provides a useful method for confirming the clinical diagnosis of PD with correlation to disease severity. Additionally, this technique allows the simultaneous measurement of SERT uptake and shows that PD patients, interestingly, seem to have decreased SERT availability in the thalamic and frontal areas.</div></front></TEI><affiliations><list><country><li>Finlande</li></country></list><tree><noCountry><name sortKey="Ahonen, A" sort="Ahonen, A" uniqKey="Ahonen A" first="A" last="Ahonen">A. Ahonen</name><name sortKey="Myllyl, V V" sort="Myllyl, V V" uniqKey="Myllyl V" first="V V" last="Myllyl">V V Myllyl</name><name sortKey="Sotaniemi, K A" sort="Sotaniemi, K A" uniqKey="Sotaniemi K" first="K A" last="Sotaniemi">K A Sotaniemi</name><name sortKey="Torniainen, P" sort="Torniainen, P" uniqKey="Torniainen P" first="P" last="Torniainen">P. Torniainen</name></noCountry><country name="Finlande"><noRegion><name sortKey="Haapaniemi, T H" sort="Haapaniemi, T H" uniqKey="Haapaniemi T" first="T H" last="Haapaniemi">T H Haapaniemi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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